Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 3.905


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GABPB1chr15_-_484348960.802.0e-04Click!
GABPAchr21_+_260291280.562.5e-02Click!
ELK4chr1_-_203868622-0.312.4e-01Click!
ELK1chrX_-_47394937-0.155.7e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_109729176 4.545 NM_023016
 ANKRD57
ankyrin repeat domain 57
chr2_+_176842368 4.446 NM_006554
 MTX2
metaxin 2
chr3_+_180348818 4.319 NM_006218
 PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide
chr2_+_27659396 3.990 NM_032434
 ZNF512
zinc finger protein 512
chr2_+_64605049 3.660 AFTPH
aftiphilin
chr7_+_107997527 3.597 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr7_+_107997544 3.563 NM_012328
 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr9_+_113433364 3.441 NM_001015882
NM_004125
 DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chr2_+_64604940 3.367 NM_001002243
NM_017657
NM_203437
 AFTPH


aftiphilin


chr7_-_107997132 3.268 NM_182529
NM_001130475
 THAP5

THAP domain containing 5

chr7_+_107171809 2.900 CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr1_+_36169260 2.765 NM_024852
NM_177422
 EIF2C3

eukaryotic translation initiation factor 2C, 3

chr9_+_114288899 2.763 NM_133465
 KIAA1958
KIAA1958
chr20_+_56659693 2.762 NM_001001433
NM_001134772
NM_001134773
NM_003763
 STX16



syntaxin 16



chr3_+_133861894 2.734 UBA5
ubiquitin-like modifier activating enzyme 5
chr2_+_74007495 2.709 DGUOK
deoxyguanosine kinase
chr9_+_114289178 2.668 KIAA1958
KIAA1958
chr2_+_74007523 2.658 DGUOK
deoxyguanosine kinase
chr2_+_74007439 2.638 NM_080916
NM_080918
 DGUOK

deoxyguanosine kinase

chr5_+_72830029 2.532 BTF3
basic transcription factor 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 115 entries
enrichment   p-value GO term description
2.60 6.57e-03 GO:0006369 termination of RNA polymerase II transcription
2.38 1.28e-04 GO:0006353 transcription termination, DNA-dependent
2.31 1.70e-03 GO:0072594 establishment of protein localization to organelle
2.15 8.32e-03 GO:0031123 RNA 3'-end processing
2.08 4.50e-09 GO:0000375 RNA splicing, via transesterification reactions
2.08 1.62e-02 GO:0022618 ribonucleoprotein complex assembly
2.06 2.13e-08 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.06 2.13e-08 GO:0000398 nuclear mRNA splicing, via spliceosome
2.02 9.33e-05 GO:0048193 Golgi vesicle transport
2.01 2.92e-02 GO:0071826 ribonucleoprotein complex subunit organization
1.92 3.74e-02 GO:0006414 translational elongation
1.90 1.27e-09 GO:0008380 RNA splicing
1.85 3.46e-11 GO:0006397 mRNA processing
1.84 8.36e-12 GO:0016032 viral reproduction
1.81 3.24e-03 GO:0006417 regulation of translation
1.79 6.68e-03 GO:0010498 proteasomal protein catabolic process
1.79 6.68e-03 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.78 2.64e-06 GO:0032446 protein modification by small protein conjugation
1.78 1.24e-05 GO:0016567 protein ubiquitination
1.76 6.39e-13 GO:0016071 mRNA metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 48 entries
enrichment   p-value GO term description
2.61 2.48e-02 GO:0030532 small nuclear ribonucleoprotein complex
2.35 1.47e-05 GO:0071013 catalytic step 2 spliceosome
2.25 7.85e-09 GO:0005681 spliceosomal complex
2.03 1.31e-02 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
1.91 8.29e-04 GO:0016607 nuclear speck
1.91 4.06e-02 GO:0000790 nuclear chromatin
1.87 4.34e-02 GO:0042470 melanosome
1.87 4.34e-02 GO:0048770 pigment granule
1.82 4.49e-16 GO:0030529 ribonucleoprotein complex
1.75 3.72e-03 GO:0044445 cytosolic part
1.74 6.16e-04 GO:0005840 ribosome
1.73 1.06e-02 GO:0031965 nuclear membrane
1.66 7.79e-04 GO:0016604 nuclear body
1.60 2.58e-03 GO:0005635 nuclear envelope
1.52 8.59e-06 GO:0005730 nucleolus
1.45 1.22e-23 GO:0044428 nuclear part
1.45 5.56e-19 GO:0031981 nuclear lumen
1.43 3.15e-12 GO:0005654 nucleoplasm
1.41 2.91e-21 GO:0031974 membrane-enclosed lumen
1.41 8.91e-21 GO:0070013 intracellular organelle lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
1.97 1.48e-02 GO:0008565 protein transporter activity
1.94 4.83e-02 GO:0008135 translation factor activity, nucleic acid binding
1.90 8.29e-03 GO:0008026 ATP-dependent helicase activity
1.90 8.29e-03 GO:0070035 purine NTP-dependent helicase activity
1.82 2.62e-04 GO:0008168 methyltransferase activity
1.77 8.89e-04 GO:0016741 transferase activity, transferring one-carbon groups
1.77 5.30e-03 GO:0003735 structural constituent of ribosome
1.66 1.72e-03 GO:0003713 transcription coactivator activity
1.60 6.33e-14 GO:0003723 RNA binding
1.51 3.79e-02 GO:0016881 acid-amino acid ligase activity
1.45 1.09e-02 GO:0003712 transcription cofactor activity
1.45 1.25e-02 GO:0000988 protein binding transcription factor activity
1.45 1.25e-02 GO:0000989 transcription factor binding transcription factor activity
1.32 7.97e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.31 1.05e-02 GO:0016817 hydrolase activity, acting on acid anhydrides
1.31 1.31e-02 GO:0016462 pyrophosphatase activity
1.30 5.29e-17 GO:0003676 nucleic acid binding
1.30 2.32e-02 GO:0017111 nucleoside-triphosphatase activity
1.25 2.50e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.25 5.47e-04 GO:0005524 ATP binding